A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine

Abstract Cardiac valve replacement is an effective method to treat valvular heart disease. Artificial valves used routinely in clinic still have defects. In our study, we explored a novel modify the performance of Decellularized Heart Valve (DHV) scaffold. The decellularized porcine aortic was prepared using sequential hydrophile and lipophile solubilization method. sericin extracted from silk fibroin-deficient silkworm cocoon by lithium bromide First, DHV immersed solution produce sericin–DHV composite Then, modified making Polydopamine (PDA) coating on first then binding sericin. physical properties biological compatibility scaffold were assessed vitro vivo. Sericin successfully prepared, combined improved its biocompatibility. PDA further promoted combination scaffolds. decay rate decreased vivo it showed good with blood. conclusion, modification biocompatibility recellularization valves, showing great potential be artificial valve.